Our team studies the functions and interactions of proteins using structural, cell, chemical and computational biology approaches. We work towards understanding the molecular mechanisms that underpin cellular functions and how these events are altered in human diseases such as cancer. We are developing new approaches that combine synthetic and computational biology to investigate and overcome…
As chemists, we build an manipulate molecules and their assembly, as well as understanding complex system. Applications include synthesis and manipulation of nanomaterials (e.g. for theranosics), understanding interactions mediating complex systems (allowing control), and uncovering mechanisms behind complex molecules (e.g. melanins)
I designed and applied engineer biology to resolve the problem in neuroscience.
In our lab we are particularly interested in engineering the chassis (the microbial cell), its genome, and its protein synthesis machinery, alongside the genetic construct itself, to fine tune the performance of such microbial cell factories for a range of applications. We use both high-throughput screening and directed evolution, as well as biochemical and cell…
Dr Sophia Tsoka centres on Biomedical Data Science and Bioinformatics, focusing on explainable AI models that integrate multi-omic and clinical data to reveal mechanisms of human disease. Her work advances interpretable deep learning, optimisation-based AI and explainable drug discovery, bridging together algorithmic developement with translational relevance across systems modelling, precision medicine and therapeutic insights.
Our research explores how intrinsically disordered proteins self-assemble to create liquid droplet-like compartments in living cells, and bio-inspired soft materials with tunable properties. By designing and functionalising disordered proteins, we aim to build intracellular ‘factories’ with novel functions, develop disordered protein-based biomaterials for targeted drug delivery, and control communication between synthetic cells and living cells.
Simulation-guided design of membrane-active peptide to functionalise cell membranes.
We have expertise on artificial cells. vesicle-based drug delivery and LNP formulations , including: 1. Metabolite-triggered drug release systems. 2. Vesicle in hydrogel drug delivery depots that can be sprayed over target tissue during laparoscopic surgery. 3. Hybrid vesicles with tuneable drug release rates. 4. Enhanced LNP formulations for improved storage stability and tissue-specific targeting….
We develop and optimise novel bioengineered in vitro models of functioning human neural circuitry, combining neurobiology, stem cell technology, engineering and microfabrication.
I am studying bio-mineralisation processes in renal and cardio-vascular systems: common mechanisms, promotors and inhibitors, role of proteins in bio-mineral deposition on vessel walls, crystallisation in biological fluids. A research topic of special interest to me is the mechanism of kidney stone formation. Everyone forms crystals in the urinary system, but they get discharged. The…