DNA engine

Our Programme

EB4B uses a project-first approach where you’ll select and start your specific research project from day one. Rather than spending months rotating through different labs, you’ll dive directly into interdisciplinary research that connects engineering biology expertise with biomedical applications.

Each project is co-supervised by an engineering domain expert and a biomedical specialist, giving you precisely the skills combination that our industry partners have identified as critically needed. This structure means you’ll develop both technical depth in cutting-edge biological engineering and breadth in therapeutic application from the outset of your PhD.

Your training begins with an intensive four-week foundation programme designed to build cohort identity and equip you with essential skills.

The first week brings all students together in person for core training across our three engineering domains (biomolecular engineering, biomaterials engineering, and bioprocessing/scale-up), workshops on entrepreneurship, metrology, regulatory challenges, research integrity, and team-building activities. Weeks two and three focus on self-directed learning, where you’ll develop transferable skills, complete group design challenges, and write a science communication article about your project. The fourth week consolidates your learning with industry partner-led sessions, professional development workshops, and crucial metrology training delivered with NPL’s PostGraduate Institute.

Beyond the foundation, you’ll progress through structured milestones guided by your personalised Development Needs Analysis (DNA). Your development is supported by regular seminars, an annual summer symposium bringing together all cohorts and partners, and opportunities for industrial placements with our network of 18 project partners.

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Beyond the foundation, you’ll progress through structured milestones guided by your personalised Development Needs Analysis (DNA). Your development is supported by regular seminars, an annual summer symposium bringing together all cohorts and partners, and opportunities for industrial placements with our network of 18 project partners.

Throughout your PhD, you’ll benefit from access to state-of-the-art facilities across King’s, Leeds, and NPL, including metrology bio-foundries, cryo-EM facilities, gene therapy innovation hubs, and high-performance computing resources. This combination of focused training, strong supervision, and world-class infrastructure prepares you for diverse careers spanning biotech entrepreneurship, industrial R&D, academic research, and regulatory affairs

Our Researchers

EB4B will train a new generation of over 40 engineering biologists who can bridge the critical gap between fundamental biological design principles and practical biomedical challenges. Our graduates will possess a unique combination of skills that industry partners have identified as critically needed but currently lacking: the ability to design biological systems, scale manufacturing processes to consistent standards, navigate complex regulatory landscapes, and develop viable commercial strategies for engineered biological therapies. You’ll join a community of researchers who are comfortable working at the interface of disciplines, connecting cutting-edge engineering biology tools with real-world therapeutic implementation.

Our graduates emerge as research leaders equipped for diverse career pathways. With deep expertise in biological engineering, computational design, and bioprocessing, combined with entrepreneurial competencies and regulatory awareness, you’ll be prepared to lead in biotech startups, pharmaceutical R&D, academic research, or policy and regulation.

The programme’s emphasis on interdisciplinary collaboration means you’ll develop not just technical mastery, but also the communication, project management, and teamwork skills essential for translating engineering biology advances into tangible healthcare benefits. Students supervised by our researchers have historically progressed to roles including independent academic positions at leading universities, research scientists in biotechnology and pharmaceutical companies, research roles in national laboratories and research institutes, science policy positions, and entrepreneurial ventures in emerging biotech startups.

Our Projects

EB4B’s mission is to connect engineering biology technical expertise with real-world biomedical challenges. Every PhD project in our programme bridges fundamental biological engineering with therapeutic application, ensuring our research addresses the critical implementation gaps that currently limit the translation of engineering biology innovations into healthcare solutions. This approach reflects the priorities identified by our industry partners and aligns with the UK’s National Engineering Biology Programme.

Our projects span three Engineering Biology Domains and three Biomedical Challenge Areas. The Engineering Biology Domains include Biomolecular Engineering (protein engineering, RNA biology, AI-driven design, and biomimetic systems), Biomaterials Engineering (membrane engineering, synthetic organelles, mechanobiology, and nanomaterials), and Bioprocessing and Scale-up (process development for manufacturing and delivery systems). These connect to three Biomedical Challenge Areas: Engineered Cellular Entry (creating new routes for therapeutic delivery across biological barriers), Programmable Microenvironments (controlling cellular niches for precision therapies), and Synthetic Cell-to-Cell Communication (engineering intercellular signaling for coordinated therapeutic responses). All projects are underpinned by metrology and standards for engineering biology, ensuring our innovations can be translated to real-world applications.

Example projects include engineering nuclease-resistant aptamers for targeted drug delivery, developing nanoneedles for efficient T-cell manufacturing in gene therapies, creating AI-optimized microreactor processes for programmable protein nanoparticles, engineering hybrid extracellular vesicles that combine natural cell-targeting with improved cargo delivery, and designing T cell therapies that actively reprogram disease microenvironments.

Browse our full portfolio of projects to discover opportunities that match your interests and career goals. Each project listing details the specific research objectives, the engineering biology domain and biomedical challenge area it addresses, the supervisory team, and the skills you’ll develop. Whether you’re passionate about molecular design, materials engineering, or scaling biological manufacturing, you’ll find projects that combine technical innovation with meaningful therapeutic impact