leeds

  • Marc de Kamps

    Dr Marc de Kamps’ expertise in computational modelling of dynamical systems and parameter identifiability aligns with Biomaterial Engineering through the in‑silico characterisation of soft‑tissue mechanics (muscle–tendon–joint). The work treats neuromuscular tissues as engineered biomaterials whose properties are measured and tuned within programmable microenvironments (task/episode states).

  • Robert Salmond

    We are interested in understanding the mechanisms that regulate T cell activation in disease, particularly cancer, and health. This encompasses analysis of T cell receptor signalling pathways and cellular metabolism. We use a combination of in vivo transgenic and knockout mouse models and in vitro cellular and molecular immunology approaches.

  • David Jayne

    David Jayne is Bowel Cancer UK and RCS Engl. Professor of Surgery and Honorary Consultant Surgeon at Leeds Teaching Hospitals NHS Trust. His research interests focus on novel therapies for colorectal cancer and preclinical cancer models through to late phase surgical trials. He has previously held a multi centre grant from the MRC/NIHR IntAct study…

  • Thomas Chamberlain

    The group works at the interface between nanomaterials science, chemistry and chemical engineering within the Institute of Process Research and Development at the University of Leeds. We are focused on exploring the relationship between the synthesis of nanomaterials and the resultant structure and performance. Our interdisciplinary team combines the synthesis of molecular and nanomaterial building…

  • Ryan Seipke

    Research throughout my career has focused on the regulation, biosynthesis, and genomics of microbial secondary metabolism, primarily that of Streptomyces species. As of Septembrer 2023, the team consists of 3 PDRAs and 3 PhD students. The lab is gateful for support received from BBSRC, InnovateUK, The Royal Society and Wellcome Trust.

  • Tuning cellular entry mechanisms for nanomaterial drug delivery platforms

    Healthcare Nanomaterials have significant application in delivering therapeutic for a variety of diseases from cancer to vaccines. The mode of entry into the cell to give the biggest payload in an effective manner is not yet realised. Currently through liposome or surface protein interaction and endocytosis are non-specific and slow kinetic driven pathways. This project…

  • Engineered nanoparticles for the uptake and imaging of colorectal cancer

    Colorectal cancer (CRC) is the third most common cancer in the UK, with 100 people diagnosed every day. Surgery is the mainstay of treatment for colorectal cancer with around 30,000 operations performed each year in the NHS. Around 50% of patients will be cured by surgery, but 10-15% will develop locoregional disease recurrence due to…

  • Improving T cell resistance to stiff tumour enviroments

    Human health faces constant challenges from environmental insults like infections, cancer, and tissue damage, with the immune system playing a key role in responding to these threats. It has become evident that immune responses are not only shaped by ligand-receptor interactions but also by biomechanical cues from the tissue environment. For example, tumour tissues, can…

  • Engineering Smart Intracellular Compartments for Directing Protein Fate

    Cells must decide the fate of every newly made membrane protein: fold it, insert it into membranes, or degrade it. These triage decisions shape protein homeostasis, disease susceptibility, and the yield of biologics. In this PhD, you will engineer programmable intracellular microenvironments that control this decision. By harnessing SGTA—a cytosolic holdase that naturally captures membrane…