Our interests lie in the nuclear envelope’s and nuclear lamina’s roles in ageing and disease. For this, we generate and characterise models of cardiac myopathy and skeletal myopathies in cells and preclinical models (mouse and iPSC-derived cells).
Research in the group is focussed on creating new methods to precisely engineer proteins. O These methods are then applied to challenges across engineering biology including precision formation of biopharmaceuticals such as antibody-drug conjugates and vaccines, and the reengineering of cells. Current major projects include IMProGlyco, an EIC-funded project, to reprogramme cellular glycosylation and ACROPATH,…
We work at the intersection of AI and synthetic biology, creating DNA and protein designs that control expression, stability, activity, and cell fate. With strong computational and experimental capability, we build predictable biological components for biomedicine, supporting advances in biologics, cell therapies, and diagnostics. Prospective applicants will join a team driving data-driven engineering biology.
Max Ryadnov leads biometrology and engineering biology research areas at NPL. He is an NPL Fellow in biometrology, professor of biophysics, director of the UK’s reference biofoundry and holds a PhD in chemistry.In his role, Max is responsible for pre-normative research, metrology and standardisation for industry, with an emphasis on sector-agnostic advanced biomanufacturing. His team…
We are engineering ribosomes and membrane protein quality-control systems to improve folding and expression of antibodies and membrane proteins. In parallel, we are manipulating liquid–liquid phase separation (LLPS) to create programmable intracellular microenvironments that control protein fate. This work will enable reliable production of complex biologics and expand therapeutic possibilities.
We use the latest generation of microscopic, tomographic and spectroscopic X-ray analysis techniques at national and international facilities (especially at Diamond Light Source, www.diamond.ac.uk, and the European Synchrotron Radiation Facility, www.esrf.fr) to establish the molecular basis for biochemical processes relevant for medicine development. This work is extremely interdisciplinary, combining aspects of biology, medicine, chemistry, physics,…
Molecular communication (MC) provides a way for nano/microdevices to communicate information over distance via chemical signals in nanometer to micrometer scale environments. To tackle the challenges on the lack of nano/micro-devices capable of processing the time-varying chemical concentration signals, my group aims to design the chemical reaction-based microfluidic MC prototypes with functionalities, including modulation and…
My work focuses on label-free methodologies to tackle biomedical problems at the single-cell level. Specifically, Raman spectroscopy, both spontaneous Raman as well as SRS and CARS imaging, and microfluidics. I am the co-chair of the HYBIFA facility, able to do multiphoton imaging characterisation of biomedical samples using label-free vibrational imaging (SRS and CARS), second harmonic…
Engineered transporters with designed substrate specificity Engineered control of biosynthetic pathways
Our research integrates engineering biology, AI and bioprocess systems engineering to design biological pathways and optimise biotechnology for sustainable food and target molecules. My lab researches waste-to-microbial protein fermentation, microbiome and retrobiosynthesis, and hybrid AI-based optimisation of bioprocesses. We also develop interpretable AI tools for toxicity and sustainability prediction, advancing safe-by-design biomanufacturing and engineering biology…